Barbarian
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Adaptive evolution is shaped by the interaction of population genetics, natural selection and underlying network and biochemical constraints. Variation created by mutation, the raw material for evolutionary change, is translated into phenotypes by flux through metabolic pathways and by the topography and dynamics of molecular networks. Finally, the retention of genetic variation and the efficacy of selection depend on population genetics and demographic history. Emergent high-throughput experimental methods and sequencing technologies allow us to gather more evidence and to move beyond the theory in different systems and populations. Here we review the extent to which recent evidence supports long-established theoretical principles of adaptation.
Determinants of fixation of adaptive alleles
The interaction of the selective coefficient (s), effective population size (Ne) and initial frequency (p0) determines the probability of fixation of an adaptive allele. The x axis is log-transformed for clarity. Homo sapiens10, Arabidopsis thaliana14 and Caenorhabditis elegans117 all have small historical Ne values (of ~10,000), and the probability of fixing a strongly adaptive allele is much lower than for populations with a high Ne (such as Drosophila melanogaster118 and Escherichia coli119, which have Ne values of 1.1 million and 25 million, respectively). Higher initial frequency increases the chances of fixation of adaptive alleles45.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748133/figure/F1/
Determinants of fixation of adaptive alleles
The interaction of the selective coefficient (s), effective population size (Ne) and initial frequency (p0) determines the probability of fixation of an adaptive allele. The x axis is log-transformed for clarity. Homo sapiens10, Arabidopsis thaliana14 and Caenorhabditis elegans117 all have small historical Ne values (of ~10,000), and the probability of fixing a strongly adaptive allele is much lower than for populations with a high Ne (such as Drosophila melanogaster118 and Escherichia coli119, which have Ne values of 1.1 million and 25 million, respectively). Higher initial frequency increases the chances of fixation of adaptive alleles45.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748133/figure/F1/