[__ Science __ ] Ivermectin is FDA-approved

[JLB]

Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite this promise, the antiviral activity of ivermectin has not been consistently proven in vivo. While ivermectin's activity against SARS-CoV-2 is currently under investigation in patients, insufficient emphasis has been placed on formulation challenges. Here, we discuss challenges surrounding the use of ivermectin in the context of coronavirus disease-19 (COVID-19) and how novel formulations employing micro- and nanotechnologies may address these concerns.

Ivermectin: an award-winning drug with expected antiviral activity against COVID-19 - PMC

Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite this promise, the ...

pmc.ncbi.nlm.nih.gov

 

[Barbarian]

Ivermectin is approved for fighting parasite infections. In the lab, it has inhibited COVID-19 virus. Testing is still not clear it if works in vivo to reduce COVID-19 viral infections.

The issue is that ivermectin can be dangerous, particularly at levels being taken in hopes of preventing COVID-19 infections.

Pharmacist details ivermectin’s dangerous snowball effect - UW Medicine | Newsroom

A powerful drug comes in multiple forms, none of which is currently recommended to treat COVID-19.

newsroom.uw.edu

Serious Neurological Adverse Events after Ivermectin—Do They Occur beyond the Indication of Onchocerciasis? - PMC

Serious neurological adverse events have been reported from large scale community-based ivermectin treatment campaigns against Onchocerciasis volvulus in Africa. The mechanism of these events has been debated in the literature, largely focusing on ...

pmc.ncbi.nlm.nih.gov

Hopefully, the trials will show a benefit at safe dosages.