St. Ephraem of Syria (c. 306-373) called Mary the “dispensatrix of all goods.” (in William G. Most, Mary in Our Life, Garden City, New York: Doubleday Image, 1963, 48)
Basil of Seleucia (died c. 458) referred to her as the “Mediatrix of God and men.” (in Most, ibid., 48)
St. Cyril of Alexandria (d. 444) wrote:
“Hail, Mary, Mother of God, by whom all faithful souls are saved.
St. Andrew of Crete (c. 660-740) referred to Mary as the “Mediatrix of the law and grace” and also stated that “she is the mediation between the sublimity of God and the abjection of the flesh.”
St. John of Damascus (c. 675-c. 749) spoke of Mary fulfilling the “office of Mediatrix.”
The Protestant reference Oxford Dictionary of the Christian Church (ed. F. L. Cross, 2nd ed., Oxford Univ. Press, 1983, p. 561), states concerning Patriarch Germanus:
“Mary’s incomparable purity, foreshadowing the doctrine of the Immaculate Conception, and her universal mediation in the distribution of supernatural blessings, are his two frequently recurring themes.”
William Most comments:
“Mary, says St. Irenaeus, undoes the work of Eve. Now it was not just in a remote way that Eve had been involved in original sin: she shared in the very ruinous act itself. Similarly, it would seem, Mary ought to share in the very act by which the knot is untied — that is, in Calvary itself.”
(in Most, ibid., 25)
“Just as the human race was bound over to death through a virgin, so was it saved through a virgin: the scale was balanced — a virgin’s disobedience by a virgin’s obedience.”
(Against Heresies, V, 19, 1; cited in Most, ibid., 274)
Justin Martyr
“[Jesus] became man by the Virgin so that the course which was taken by disobedience in the beginning through the agency of the serpent might be also the very course by which it would be put down. Eve, a virgin and undefiled, conceived the word of the serpent and bore disobedience and death. But the Virgin Mary received faith and joy when the angel Gabriel announced to her the glad tidings that the Spirit of the Lord would come upon her and the power of the Most High would overshadow her, for which reason the Holy One being born of her is the Son of God. And she replied ‘Be it done unto me according to your word’ [Luke 1:38]” (Dialogue with Trypho the Jew 100 [A.D. 155]).
Irenaeus
“Consequently, then, Mary the Virgin is found to be obedient, saying, ‘Behold, O Lord, your handmaid; be it done to me according to your word.’ Eve, however, was disobedient, and, when yet a virgin, she did not obey. Just as she, who was then still a virgin although she had Adam for a husband—for in paradise they were both naked but were not ashamed; for, having been created only a short time, they had no understanding of the procreation of children, and it was necessary that they first come to maturity before beginning to multiply—having become disobedient, was made the cause of death for herself and for the whole human race; so also Mary, betrothed to a man but nevertheless still a virgin, being obedient, was made the cause of salvation for herself and for the whole human race. . . . Thus, the knot of Eve’s disobedience was loosed by the obedience of Mary. What the virgin Eve had bound in unbelief, the Virgin Mary loosed through faith” (Against Heresies 3:22:24 [A.D. 189]).
“The Lord then was manifestly coming to his own things, and was sustaining them by means of that creation that is supported by himself. He was making a recapitulation of that disobedience that had occurred in connection with a tree, through the obedience that was upon a tree [i.e., the cross]. Furthermore, the original deception was to be done away with—the deception by which that virgin Eve (who was already espoused to a man) was unhappily misled. That this was to be overturned was happily announced through means of the truth by the angel to the Virgin Mary (who was also [espoused] to a man). . . . So if Eve disobeyed God, yet Mary was persuaded to be obedient to God. In this way, the Virgin Mary might become the advocate of the virgin Eve. And thus, as the human race fell into bondage to death by means of a virgin, so it is rescued by a virgin. Virginal disobedience has been balanced in the opposite scale by virginal obedience. For in the same way, the sin of the first created man received amendment by the correction of the First-Begotten” (ibid., 5:19:1 [A.D. 189]).
Tertullian
“It was while Eve was still a virgin that the word of the devil crept in to erect an edifice of death. Likewise through a virgin the Word of God was introduced to set up a structure of life. Thus what had been laid waste in ruin by this sex was by the same sex reestablished in salvation. Eve had believed the serpent; Mary believed Gabriel. That which the one destroyed by believing, the other, by believing, set straight” (The Flesh of Christ 17:4 [A.D. 210].
Ephraim the Syrian
“You alone and your Mother are more beautiful than any others, for there is no blemish in you nor any stains upon your Mother. Who of my children can compare in beauty to these?” (Nisibene Hymns 27:8 [A.D. 361]).