Boidae,
First of all, I'm so glad you finally have a job... praise God!!!
My niece has MS and has had 4 pregnancies. Each time she was extremely fatigued. Most of the time, she's really on the ball and no one would ever know how sick she is... but during her pregnancies she really needed a lot of rest. Usually, whenever she's been pregnant, either her mother or her mother-in-law were there to do the housework, allowing her to simply rest...even if rest was getting out of the house for a while. I mean that... for pretty much the entire pregnancy and up to about a month or so after the babies were born, my sister would go and live with them for weeks to months and when she couldn't be there, my niece's mother-in-law would come to help. This isn't because my niece is lazy... the MS combined with the pregnancy just caused her to not be able to do much at all.
It doesn't sound as if your wife has the support of women in her family like my niece does. So, it's all falling on you.
Housework can become very overwhelming if one is already fatigued and also if one is dealing with depression... which your wife very well may be. Also, it sounds as if she's never been much of a housekeeper and you've done the job for quite a while. Now, you're working, she's not except for a day or two and things aren't getting done.
She sounds very defensive about the whole thing... you haven't shared what she says is her reason for not doing a reasonable amount of housework so I'm assuming she isn't giving one, but rather becoming defensive and going on the attack with the "you're trying to control me" accusation.
The fact that she's being so defensive (if I have that part right) is probably because she's feeling under conviction about the whole thing and isn't up to dealing with it. So, she's avoiding it by going out with friends and pushing it back on you via the "control" accusation.
The key to being able to unravel all of this is to be able to have meaningful conversation where she isn't becoming defensive and the whole thing dissolving into an argument. I think that's where you need to start with her... not on the issue of the housework itself, but on the fact that the two of you need to have a constructive conversation about it, where both of you feel free to express what's really going on in each of your hearts without feeling like the other is going to go on the attack.
Once you've come to a real understanding of what's really in her heart about this whole issue, then you can work towards resolving it. At this point, I don't think you do have that understanding. Because if you did, I think you would have shared with us what it is... as it is, you seem clueless about why she's acting this way.