Hi there. Just want to clarify something. By "macro-evolution", you're referring to speciation, right?
That is what scientists mean by "macroevolution."
Speciation is the process of one species splitting into multiple, "descending". A species is defined as a population which is capable of breeding and producing viable offspring with each other. That's it. The line is pretty weak. One species is only separated by another by this tenuous condition.
Yes, and it's a serious problem for creationism. If creationism were true, there would be nice, definable boundaries between taxa. But there are all sorts of intermediate cases, as Darwin pointed out in his book. No creationist has found a satisfactory answer for this. And YE creationist Kurt Wise admits, it's almost as daunting a challenge as the many, many examples of transitional forms in the fossil record.
Mutations and allele are both causes of speciation.
What do you think "allele" means? That sentence seems meaningless.
Interbreeding can be prevented by physical separation, physical and behavioral incompatibilities and chromosomal differences. A extra or missing chromosome(aneuploidy) wont necessarily make an animal at a disadvantage.
It's generally lethal or disabling in animals, but less so in other kingdoms. Aneuploidy is a common form of macroevolution in plants, for example.
There is one possible case of polyploidy speciation in mammals,but the evidence is ambiguous.
We mostly pay attention to the disorders chromsonal abnormality causes, but these abnormalities often don't cause issues. Especially in non-humans.[/quote]
It's usually a very bad thing, but can actually be an agency of evolution in some cases. Humans differ from other apes by a chromosome fusion, for example.
You also can't forget, Darwin was wrong about plenty of things
He thought inheritance was humoral, rather than particulate, for example.
and the current understanding of evolution isn't represented by his book.
His four basic claims remain validated as much as ever. But he had some things wrong. Most notably, he knew nothing of genetics, as Mendel's discoveries were not well-known until the 20th century. Too bad, since genetics cleared up a very difficult problem in his theory. Would you like to talk about that?
Here's an intersting story about a man with 44 chromosomes and no symptoms. Except it wouldn't be easy for him to reproduce with a normal woman.
Interesting case. He's not missing any genetic material; he's got both chromosome 14s fused with chromosomes 15. So he has the same genes as everyone else, but of course, at meiosis, the gametes wouldn't form a viable embryo with a normal human egg. Or rather are highly unlikely to do so.