Interesting. Here is God telling Adam and Eve to have children before they were kicked out of Eden.
Genesis 1:
27 So God created man in his own image, in the image of God created he him; male and female created he them.
28 And God blessed them, and God said unto them, Be fruitful, and multiply, and replenish the earth, and subdue it: and have dominion over the fish of the sea, and over the fowl of the air, and over every living thing that moveth upon the earth.
But only man was sent out of Eden.
Genesis 3:
22 And the LORD God said, Behold, the man is become as one of us, to know good and evil: and now, lest he put forth his hand, and take also of the tree of life, and eat, and live for ever:
23 Therefore the LORD God sent him forth from the garden of Eden, to till the ground from whence he was taken.
24 So he drove out the man; and he placed at the east of the garden of Eden Cherubims, and a flaming sword which turned every way, to keep the way of the tree of life.
Genesis 4:
1 And Adam knew Eve his wife; and she conceived, and bare Cain, and said, I have gotten a man from the LORD.
2 And she again bare his brother Abel. And Abel was a keeper of sheep, but Cain was a tiller of the ground.
Adam only knows his wife Eve after they were sent out of Eden. And then Eve says she has gotten a man from the LORD. She says this for the first time.
Adam and Eve didn't have children until after they were sent away from Eden.
So we can be sure from the Scriptures.