Lewis
Member
SAN DIEGO — Imagine a vaccine against smoking: People trying to quit would light up a cigarette and feel nothing. Or a vaccine against cocaine, one that would prevent addicts from enjoying the drug’s high.
For 27 years, Dr. Janda has pursued vaccines to blunt drugs' effects.
Though neither is imminent, both are on the drawing board, as are vaccines to combat other addictions. While scientists have historically focused their vaccination efforts on diseases like polio, smallpox and diphtheria — with great success — they are now at work on shots that could one day release people from the grip of substance abuse.
“We view this as an alternative or better way for some people,†said Dr. Kim D. Janda, a professor at the Scripps Research Institute who has made this his life’s work. “Just like with nicotine patches and the gum, all those things are just systems to get people off the drugs.â€
Dr. Janda, a gruff-talking chemist, has been trying for more than 25 years to create such a vaccine. Like shots against disease, these vaccines would work by spurring the immune system to produce antibodies that would shut down the narcotic before it could take root in the body, or in the brain.
Unlike preventive vaccines — like the familiar ones for mumps, measles and so on — this type of injection would be administered after someone had already succumbed to an addictive drug. For instance, cocaine addicts who had been vaccinated with one of Dr. Janda’s formulations before they snorted cocaine reported feeling like they’d used “dirty coke,†he said. “They felt like they were wasting their money.â€
It’s a novel use for vaccines that has placed Dr. Janda, who is 54, in the vanguard of addiction treatment. Because addiction is now thought to cause physical changes in the brain, doctors increasingly advocate medical solutions to America’s drug problem, leading to renewed interest in his work.
“It’s very fashionable now,†said Dr. Janda, seated in a black leather chair in his office. “When we started doing this 27 years ago, it wasn’t.â€
In July, Dr. Janda’s lab — 25 researchers, most of graduate-school age — made headlines when it announced that it had produced a vaccine that blunted the effects of heroin in rats. Rodents given the vaccine didn’t experience the pain-deadening effects of heroin and stopped helping themselves to the drug, presumably because it ceased to have any effect.
But as has often been the case in Dr. Janda’s career, the breakthrough came on the heels of a setback: A Phase 2 clinical trial for a nicotine vaccine that was based largely on his work was declared a failure this summer when people receiving the drug quit smoking at the same rate as people receiving a placebo.
To this day, despite many promising breakthroughs, not one of Dr. Janda’s vaccines has won approval from the Food and Drug Administration. For despite many successes in the lab — including promising animal tests — the vaccines have yet to produce consistent results in humans during clinical trials.
“It’s like having the carrot right in front of the horse,†he said. “The big problem plaguing these vaccines right now is difficulty predicting in humans how well it’s going to work.â€
Or, he added, “maybe I’m just unlucky.â€
The scientific principle behind Dr. Janda’s vaccines is, as he put it, “simplistically stupid.†Much like vaccines against disease, they introduce a small amount of the foreign substance into the blood, causing the immune system to create antibodies that will attack that substance the next time it appears.
The difficulty is that molecules like cocaine, nicotine and methamphetamine are tiny — much smaller than disease molecules — so the immune system tends to ignore them. To overcome that, Dr. Janda attaches a hapten — which is either a bit of the drug itself, or a synthetic version of it — to a larger protein that acts as a platform. The last part of the vaccine is an adjuvant, a chemical cocktail that attracts the immune system’s notice, effectively tricking it into making antibodies against a substance it usually wouldn’t see.
“It’s not like some magical premise,†Dr. Janda said. “And the beauty of it is you’re not messing with brain chemistry.â€
The contrast, he said, is to anti-opiates like Suboxone or methadone that are currently used to treat heroin addiction. Rather than blocking the drug’s effects, they seek to replace the heroin high.
Dr. Janda says he has tried and failed to make vaccines against alcohol and marijuana abuse. In the case of alcohol, he said, ethanol molecules proved just too small to attach to the protein that would deliver the immunity. And in the case of marijuana, the main ingredient that produces the high — tetrahydrocannabinol, or THC — hides too well inside the body.
He has also tried formulating a vaccine against obesity. Rather than block a foreign substance, that vaccine would block the effects of a peptide hormone produced by the stomach called ghrelin that signals hunger in the brain. So far, a version of the vaccine has been shown to lower food intake in animals, though — again — it’s unclear whether it will work in humans.
Even so, addicts and their families are clamoring to get into Dr. Janda’s clinical trials. He says he gets e-mails every week from addicts asking to be included. He has had to turn away parents who showed up at his office with their drug-addicted children after reading about his work.
For 27 years, Dr. Janda has pursued vaccines to blunt drugs' effects.
Though neither is imminent, both are on the drawing board, as are vaccines to combat other addictions. While scientists have historically focused their vaccination efforts on diseases like polio, smallpox and diphtheria — with great success — they are now at work on shots that could one day release people from the grip of substance abuse.
“We view this as an alternative or better way for some people,†said Dr. Kim D. Janda, a professor at the Scripps Research Institute who has made this his life’s work. “Just like with nicotine patches and the gum, all those things are just systems to get people off the drugs.â€
Dr. Janda, a gruff-talking chemist, has been trying for more than 25 years to create such a vaccine. Like shots against disease, these vaccines would work by spurring the immune system to produce antibodies that would shut down the narcotic before it could take root in the body, or in the brain.
Unlike preventive vaccines — like the familiar ones for mumps, measles and so on — this type of injection would be administered after someone had already succumbed to an addictive drug. For instance, cocaine addicts who had been vaccinated with one of Dr. Janda’s formulations before they snorted cocaine reported feeling like they’d used “dirty coke,†he said. “They felt like they were wasting their money.â€
It’s a novel use for vaccines that has placed Dr. Janda, who is 54, in the vanguard of addiction treatment. Because addiction is now thought to cause physical changes in the brain, doctors increasingly advocate medical solutions to America’s drug problem, leading to renewed interest in his work.
“It’s very fashionable now,†said Dr. Janda, seated in a black leather chair in his office. “When we started doing this 27 years ago, it wasn’t.â€
In July, Dr. Janda’s lab — 25 researchers, most of graduate-school age — made headlines when it announced that it had produced a vaccine that blunted the effects of heroin in rats. Rodents given the vaccine didn’t experience the pain-deadening effects of heroin and stopped helping themselves to the drug, presumably because it ceased to have any effect.
But as has often been the case in Dr. Janda’s career, the breakthrough came on the heels of a setback: A Phase 2 clinical trial for a nicotine vaccine that was based largely on his work was declared a failure this summer when people receiving the drug quit smoking at the same rate as people receiving a placebo.
To this day, despite many promising breakthroughs, not one of Dr. Janda’s vaccines has won approval from the Food and Drug Administration. For despite many successes in the lab — including promising animal tests — the vaccines have yet to produce consistent results in humans during clinical trials.
“It’s like having the carrot right in front of the horse,†he said. “The big problem plaguing these vaccines right now is difficulty predicting in humans how well it’s going to work.â€
Or, he added, “maybe I’m just unlucky.â€
The scientific principle behind Dr. Janda’s vaccines is, as he put it, “simplistically stupid.†Much like vaccines against disease, they introduce a small amount of the foreign substance into the blood, causing the immune system to create antibodies that will attack that substance the next time it appears.
The difficulty is that molecules like cocaine, nicotine and methamphetamine are tiny — much smaller than disease molecules — so the immune system tends to ignore them. To overcome that, Dr. Janda attaches a hapten — which is either a bit of the drug itself, or a synthetic version of it — to a larger protein that acts as a platform. The last part of the vaccine is an adjuvant, a chemical cocktail that attracts the immune system’s notice, effectively tricking it into making antibodies against a substance it usually wouldn’t see.
“It’s not like some magical premise,†Dr. Janda said. “And the beauty of it is you’re not messing with brain chemistry.â€
The contrast, he said, is to anti-opiates like Suboxone or methadone that are currently used to treat heroin addiction. Rather than blocking the drug’s effects, they seek to replace the heroin high.
Dr. Janda says he has tried and failed to make vaccines against alcohol and marijuana abuse. In the case of alcohol, he said, ethanol molecules proved just too small to attach to the protein that would deliver the immunity. And in the case of marijuana, the main ingredient that produces the high — tetrahydrocannabinol, or THC — hides too well inside the body.
He has also tried formulating a vaccine against obesity. Rather than block a foreign substance, that vaccine would block the effects of a peptide hormone produced by the stomach called ghrelin that signals hunger in the brain. So far, a version of the vaccine has been shown to lower food intake in animals, though — again — it’s unclear whether it will work in humans.
Even so, addicts and their families are clamoring to get into Dr. Janda’s clinical trials. He says he gets e-mails every week from addicts asking to be included. He has had to turn away parents who showed up at his office with their drug-addicted children after reading about his work.
