I think my problem with a definite NO from God is the finality of it. I mean, what do you say or do when your creator gives you a thumbs down? But sometimes, God's "no" at that moment leads to something much better, much more fulfilling and meaningful later on.
Example: When I first started posting here, I was living in a small, southern town about 4 hours from the small, southern town I'm from. I prayed and prayed and prayed for a job, for job training, for..anything job related, really. I got nothing. In fact, I not only got nothing, my land lord blamed a problem in my apartment on me and refused to renew my lease, so I had to move home. Awesome.
But now I'm home and I'm getting job training. I have friends. I'm healthier, mentally and physically. My family and I are closer than ever before.
I know that not all of God's "no" responses will necessarily lead to something like that. Someone might die or, in the case of an acquaintance of mine recently, end up paralyzed for life. I guess this is where obedience and trust come in. God is not a man that He should lie....we can trust Him. In fact, I've come to the conclusion that really the only way to stay reasonably sane and joyful in this world of ours is to trust Him.