The differences continue though....
Wong. K., “Tiny Genetic Differences between Humans and Other Primates Pervade the Genome”, Scientific American, Sept. 2014, reveals that the “…tiny portion of unshared DNA makes a world of difference: it gives us, for instance, our bipedal stance and the ability to plan missions to Mars. Scientists do not yet know how most of the DNA that is uniquely ours affects gene function.” And though the recent comparisons are performed on only about 33% of the genome, “individual differences pervade the genome, affecting each of our chromosomes in numerous ways.”
In some of the presentations in articles and texts I see a language of persuasion! For example, IMWO the “only 1.8% difference” language describing the similarity between humans and chimps is just an opinion! The actual difference is more like 5% (National Geographic claims 4% but close enough to show the smaller number to be enhanced) and most scientists agree.
In the limited sections of the genome accessed, exploring the limited aspects of the genome that they used to derive these figures, add to that the fact that the common person will not bother to understand, most are simply persuaded by the appeal to authority, and by faith in statistics (see How to Lie with Statistics, by Darrell Huff…a must read for any statisticians). Actually a complete genome comparison of human and chimp DNA has never been done (period)! However the masses are given this impression (the art of persuasion), and yet the details are not clarified.
The very best and most complete study so far as far as I know is Fujiyama, A., Watanabe, H., Toyoda, A., Taylor, T.D., Itoh, T., Tsai, S.F., Park, H.S., Yaspo, M.L., Lehrach, H., Chen, Z., Fu, G., Saitou, N., Osoegawa, K., de Jong, P.J., Suto, Y., Hattori, M., and Sakaki, Y., 2002, ‘Construction and analysis of a Human-Chimpanzee Comparative Clone Map.’ Science 295:131-134 and that study only utilized 19.8 million base pairs. Though this sounds huge, it really is not….it is really quite miniscule. Nothing learned in this study should be generalized as an overall fact.
In addition, in the Britten study (Britten, R.J. 2002. ‘Divergence between samples of chimpanzee and human DNA sequences is 5% counting indels.’ Proceedings National Academy Science 99:13633-13635) the team used only 779,000 base pairs. The study concludes 1.4% of the bases were “substitutions” (meaning completely different, and not actually one thing once that has been “substituted” later), plus they also added the additional number of indels (what can be “interpreted” as insertions or deletions when comparing one genome to another).
But remember, this was what was found using ONLY around 800,000 base pairs. Some indels were small sections being only 1 to 4 nucleotides in length, but others were quite large (even as much as 1000 base pairs long). These additional indels have been added into the alleged “percentile” similarity/difference conclusion changing the figure from 1.8 to 5%. Now multiply that out for the complete genome and the differences are nearing astronomical (but that will come in time). But even when speaking from this limited perspective, as slight as even 5 % may sound, that difference is HUGE.
The Human Haploid Genome contains around 3 BILLION base pairs. Now if we take away the approximate 2,010,000,000 similar pairs (around 67%), that actually contain many differences in function, that leaves 990,000,000 base pairs of which around 1/6th definitely vary, which means there may be around 165,000,000 differences in just these base pairs between humans and chimps. That is just one of the ways to look at it. Another straight forward comparison shows there to be about 120,000,000 base pairs as differing (4% of 3,000,000,000). Again, despite the rhetorical manipulations which make us think we are almost the same, that is a huge number of differences (especially considering THE FACT that we do not even understand the purpose and function of but a few % of the genome itself…see the Encode Project).
As for the near 67% (shared by all species categorized “Primate”) as appearing to be nearly identical (most of which translates into our having blood vessels, skin, a heart pump, a brain and so on), this still does not mean one came from the other….but based on the way we have determined to categorize things this really only means we all fit in that man-determined category…nothing else! Via this section first we are a living creature, then we all are mammals, with hair, and genitalia, feeding our young via mammary glands, and so on, and within that we are all primates. But the Encode project is discovering what was thought to be the same genes function differently and even combine differently in expression.
I would suggest (a personal hypothesis) that we will find these unique combinations and functions will differ from one species to another widening the gap. But that aside, the approximated “5% difference” exists only in the other 33% which means we have an actual difference of about 1/6th of what makes us human as opposed to what makes chimps ape, and that number of differences in the base pairs is still in the millions of differences (most of which we do not even understand at this point, though we are coming along).
Why not just say we have found at least 120,000,000 differences?
When stated like that (just the data)…if we count the number of possible functions and forms possibly effected, IMO it’s like the difference between arithmetic and calculus. The amount of information encoded in over 120 million base pairs is unfathomable. Plus we have barely scraped the surface of what this means. It is actually more information than a whole think tank of genius level scientists could ever contain in 10 lifetimes compared to a think tank with only the knowledge held by any general group of common persons in 10 lifetimes. See the difference? Vast, and incomprehensible, to say the least.
I guess what I would like people to see is how when we look at declared statistics of the very same genomic portrait from a different prospective area of approach, what a different picture we get. What is emphasized…the apparent smallness of numeric representation ”5%” or the reality of over 120,000,000 differences in just this small section of the genome?
Why not loudly announce to the public that we have found at least 120,000,000 differences just in this limited portion of their genomes? I believe because it is counter to the status quo hypothesis...
(more differences to come)