Proper understanding of Rom 9:22 (not 21) is found in the actual Greek word for "prepare".
katartizō
1) to render, i.e. to fit, sound, complete
1a) to mend (what has been broken or rent), to repair
1a1) to complete
1b) to fit out, equip, put in order, arrange, adjust
1b1) to fit or frame for one’s self, prepare
1c) ethically: to strengthen, perfect, complete, make one what he ought to be
It should be clear that meanings 1, 1a1, or 1c does not fit the verse.
So, what is left? Those going to destruction have been mended, repaired, or adjusted for destruction.
IOW, they have been retro-fitted for destruction. No one has been created for destruction.